Multiple Ca2+-Dependent Mechanisms Regulate L-Type Ca2+ Current in Retinal Amacrine Cells

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Multiple Ca2+-dependent mechanisms regulate L-type Ca2+ current in retinal amacrine cells.

Understanding the regulation of L-type voltage-gated Ca(2+) current is an important component of elucidating the signaling capabilities of retinal amacrine cells. Here we ask how the cytosolic Ca(2+) environment and the balance of Ca(2+)-dependent effectors shape native L-type Ca(2+) channel function in these cells. To achieve this, whole cell voltage clamp recordings were made from cultured am...

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Multiple Ca -Dependent Mechanisms Regulate L-Type Ca Current in Retinal Amacrine Cells

Tekmen M, Gleason E. Multiple Ca -dependent mechanisms regulate L-type Ca current in retinal amacrine cells. J Neurophysiol 104: 1849 –1866, 2010. First published August 4, 2010; doi:10.1152/jn.00031.2010. Understanding the regulation of L-type voltage-gated Ca current is an important component of elucidating the signaling capabilities of retinal amacrine cells. Here we ask how the cytosolic Ca...

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Retinal amacrine cells are depolarized by the excitatory synaptic input from bipolar cells. When a graded depolarization exceeds the threshold level, trains of action potentials are generated. There have been several reports that both spikes and graded depolarization are sensitive to tetrodotoxin (TTX). In the present study, we investigated the contribution of voltage-gated currents to membrane...

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ژورنال

عنوان ژورنال: Journal of Neurophysiology

سال: 2010

ISSN: 0022-3077,1522-1598

DOI: 10.1152/jn.00031.2010